6 research outputs found
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
- Author
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Akbani Rehan
- Akeredolu Teniola
- Ally Adrian
- Anderson Matthew L.
- Anur Pavana
- Appelbaum Elizabeth L.
- Armenia Joshua
- Auman J. Todd
- Bailey Matthew H.
- Baker Laurence
- Balasundaram Miruna
- Balu Saianand
- Barthel Floris P.
- Bartlett John
- Baylin Stephen B.
- Behera Madhusmita
- Belyaev Dmitry
- Bennett Joesph
- Benz Christopher
- Beroukhim Rameen
- Birrer Michael
- Bocklage Thèrése
- Bodenheimer Tom
- Boice Lori
- Bootwalla Moiz S.
- Bowen Jay
- Bowlby Reanne
- Boyd Jeff
- Brohl Andrew S.
- Brooks Denise
- Byers Lauren
- Carlsen Rebecca
- Castro Patricia
- Chen Hsiao-Wei
- Cherniack Andrew D.
- Chibon Fréderic
- Chin Lynda
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Cibulskis Carrie
- Cooper Lee A.D.
- Cope Leslie
- Cordes Matthew G.
- Crain Daniel
- Curley Erin
- Danilova Ludmila
- Dao Fanny
- Davis Ian J.
- Davis Lara E.
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Demetri George D.
- Demicco Elizabeth G.
- Dhalla Noreen
- Diao Lixia
- Ding Li
- DiSaia Phil
- Dottino Peter
- Doyle Leona A.
- Drill Esther
- Dubina Michael
- Eschbacher Jennifer
- Fedosenko Konstantin
- Felau Ina
- Ferguson Martin L.
- Frazer Scott
- Fronick Catrina C.
- Fulidou Victoria
- Fulton Lucinda A.
- Fulton Robert S.
- Gabriel Stacey B.
- Gao Jianjiong
- Gao Qingsong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gay Carl M.
- Gehlenborg Nils
- Gerken Mark
- Getz Gad
- Godwin Andrew K.
- Godwin Eryn M.
- Gordienko Elena
- Grilley-Olson Juneko E.
- Gutman David A.
- Gutmann David H.
- Hayes D. Neil
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary
- Helsel Carmen
- Hepperla Austin J.
- Higgins Kelly
- Hoadley Katherine A.
- Hobensack Shital
- Holt Robert A.
- Hoon Dave B.
- Hornick Jason L.
- Hoyle Alan P.
- Hu Xin
- Huang Mei
- Hutter Carolyn M.
- Iacocca Mary
- Ingram Davis R.
- Ittmann Michael
- Iype Lisa
- Jefferys Stuart R.
- Jones Corbin D.
- Jones Kevin B.
- Jones Steven J.M.
- Kalir Tamara
- Karlan Beth Y.
- Karseladze Apollon
- Kasaian Katayoon
- Kim Jaegil
- Kundra Ritika
- Kuo Hanluen
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Larsson Erik
- Lawrence Michael S.
- Lazar Alexander J.
- Lee Darlene
- Lee Sanghoon
- Lehmann Kjong-Van
- Leraas Kristen M.
- Lester Jenny
- Levine Douglas A.
- Li Irene
- Lichtenberg Tara M.
- Lin Pei
- Liu Eric Minwei
- Liu Jia
- Liu Wenbin
- Lolla Laxmi
- Lu Yiling
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocco Anthony
- Maki Robert G.
- Mallery David
- Manikhas Georgy
- Mardis Elaine R.
- Mariamidze Armaz
- Marra Marco A.
- Martignetti John A.
- Martinez Cathleen
- Mayo Michael
- McLellan Michael D.
- Meier Sam
- Meng Shaowu
- Meyerson Matthew
- Mieczkowski Piotr A.
- Miller Christopher A.
- Mills Gordon B.
- Moore Richard A.
- Morris Scott
- Mose Lisle E.
- Mozgovoy Evgeny
- Mungall Andrew J.
- Mungall Karen
- Nalisnik Michael
- Naresh Rashi
- Newton Yulia
- Noble Michael S.
- Novak Janet E.
- Ochoa Angelica
- Olvera Narciso
- Owonikoko Taofeek K.
- Paklina Oxana
- Parfitt Jeremy
- Parker Joel S.
- Pastore Alessandro
- Paulauskis Joseph
- Penny Robert
- Pereira Elena
- Perou Amy H.
- Perou Charles M.
- Pihl Todd
- Pollock Raphael E.
- Potapova Olga
- Radenbaugh Amie J.
- Ramalingam Suresh S.
- Ramirez Nilsa C.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Reilly Colleen
- Reynolds Sheila M.
- Riedel Richard F.
- Roach Jeffrey
- Robertson A. Gordon
- Roszik Jason
- Rubin Brian P.
- Sadeghi Sara
- Saksena Gordon
- Salner Andrew
- Sanchez-Vega Francisco
- Sander Chris
- Schein Jacqueline E.
- Schmidt Heather K.
- Schultz Nikolaus
- Schumacher Steven E.
- Sekhon Harman
- Senbabaoglu Yasin
- Setdikova Galiya
- Shelton Candace
- Shelton Troy
- Shen Ronglai
- Shi Yan
- Shih Juliann
- Shmulevich Ilya
- Sica Gabriel L.
- Simons Janae V.
- Singer Samuel
- Sipahimalani Payal
- Skelly Tara
- Socci Nicholas
- Sofia Heidi J.
- Soloway Matthew G.
- Spellman Paul
- Sun Qiang
- Swanson Patricia
- Tam Angela
- Tan Donghui
- Tarnuzzer Roy
- Thiessen Nina
- Thompson Eric
- Thorne Leigh B.
- Tong Pan
- Torres Keila E.
- van de Rijn Matt
- Van Den Berg David J.
- Van Tine Brian A.
- Veluvolu Umadevi
- Verhaak Roel
- Voet Doug
- Voronina Olga
- Wan Yunhu
- Wang Jing
- Wang Zhining
- Weinstein John N.
- Weisenberger Daniel J.
- Wilkerson Matthew D.
- Wilson Richard K.
- Wise Lisa
- Wong Tina
- Wong Winghing
- Wrangle John
- Wu Ye
- Wyczalkowski Matthew
- Yang Liming
- Yau Christina
- Yellapantula Venkata
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Jiashan (Julia)
- Zmuda Erik
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (, , ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types
Novel genotype-phenotype associations in human cancers enabled by advanced molecular platforms and computational analysis of whole slide images
- Author
- A Janowczyk
- A Janowczyk
- A Peraud
- A Perry
- A. H. Beck
- AM Khan
- C Kandoth
- C Wang
- Cancer Genome Atlas N
- Cancer Genome Atlas N
- Cancer Genome Atlas Research N
- Cancer Genome Atlas Research N
- Cancer Genome Atlas Research N
- Cancer Genome Atlas Research N
- CL Appin
- DA Gutman
- DA Gutman
- Daniel J Brat
- David A Gutman
- DN Louis
- F Wang
- F Wang
- H Chang
- H Chang
- H Noushmehr
- J Chappelow
- J Cheng
- J Hipp
- J Kong
- Jun Kong
- K Aldape
- K Mosaliganti
- K Mosaliganti
- LA Cooper
- LA Cooper
- LAD Cooper
- Lee AD Cooper
- M Gupta
- ME Hegi
- Michael Nalisnik
- MJ van den Bent
- MN Gurcan
- MS Carro
- O Gevaert
- PA Bautista
- PA Bautista
- PO Zinn
- R Jain
- RG Verhaak
- S Kothari
- S Kothari
- S Roy Chowdhuri
- S Samsi
- VG Tusher
- W Hsu
- W Huang da
- WC Rutledge
- William D Dunn
- X Qi
- Y Murakami
- Y Song
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Scalable analysis of Big pathology image data cohorts using efficient methods and high-performance computing strategies
- Author
- A Cavallaro
- A Körbes
- A Pentland
- A Sbober
- A Strehl
- AAT Bui
- AWM Smeulders
- B Minaei-Bidgoli
- C Augonnet
- C Carson
- C Thies
- C Webb
- C-K Luk
- DAB Lindberg
- Daihou Wang
- David J. Foran
- DJ Foran
- DJ Luo
- E Chang
- EC Filippi-Chiela
- EW Forgy
- F Meyer
- F Wang
- F Wang
- Fusheng Wang
- G Bradski
- G Teodoro
- G Teodoro
- George Teodoro
- GF Diamos
- H Muller
- HC Akakin
- HD Tagare
- HL Tang
- I El-Naqa
- IJ Cox
- J Hartigan
- J Kong
- J Kong
- J Kong
- J Naik
- J Phan
- J Wang
- J Zhang
- Joel Saltz
- JR Smith
- JS Vetter
- KW Eliceiri
- L Vincent
- L Yang
- L Yang
- L Yang
- L Yang
- L Zheng
- LAD Cooper
- LAD Cooper
- Lee Cooper
- Lin Yang
- M Flickener
- M Hernández
- M Kaspar
- MD Linderman
- MEL Mattie
- MG Kahn
- Michael Nalisnik
- MM Rahman
- MN Gurcan
- N Carriero
- N Iam-on
- O Sertel
- P Forero
- P Hore
- P Schmidt-Saugenon
- Q Zhang
- R Beroukhim
- S Asur
- S Beretti
- S Monti
- S Tomov
- SP Lloyd
- T Millstein
- Tahsin Kurc
- TB Jablin
- TM Lehmann
- TM Lehmann
- V Volkov
- VT Ravi
- W Chen
- X Hu
- X Huo
- X Qi
- Xin Qi
- Y Chen
- Y Huang
- Y Wang
- Z Fang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
- Author
- A. Gordon Robertson
- Adam Abeshouse
- Adrian Ally
- Akbani
- Alan P. Hoyle
- Alessandro Pastore
- Alexander J. Lazar
- Alexandrov
- Amie J. Radenbaugh
- Amy H. Perou
- Andrew D. Cherniack
- Andrew J. Mungall
- Andrew K. Godwin
- Andrew S. Brohl
- Andrew Salner
- Angela Tam
- Angelica Ochoa
- Anthony Magliocco
- Apollon Karseladze
- Apurva M. Hegde
- Armaz Mariamidze
- Austin J. Hepperla
- Barretina
- Beck
- Beth Y. Karlan
- Bibikova
- Bindea
- Brian A. Van Tine
- Brian P. Rubin
- Budczies
- Burgess
- Candace Shelton
- Carl M. Gay
- Carmen Helsel
- Carolyn M. Hutter
- Carrie Cibulskis
- Carter
- Cathleen Martinez
- Catrina C. Fronick
- Chandrajit P. Raut
- Charles M. Perou
- Chris Sander
- Christina Yau
- Christopher A. Miller
- Christopher Benz
- Chu
- Cibulskis
- Cibulskis
- Cingolani
- Clement Adebamowo
- Colleen Reilly
- Corbin D. Jones
- Costello
- D. Neil Hayes
- Daniel Crain
- Daniel J. Weisenberger
- Darlene Lee
- Dave B. Hoon
- David A. Gutman
- David H. Gutmann
- David I. Heiman
- David J. Van Den Berg
- David Mallery
- Davis R. Ingram
- De Monte
- Dees
- Delespaul
- Denise Brooks
- Dennis T. Maglinte
- Ding
- Dmitry Belyaev
- Donghui Tan
- Doug Voet
- Douglas A. Levine
- Elaine R. Mardis
- Elena Gordienko
- Elena Pereira
- Elizabeth G. Demicco
- Elizabeth L. Appelbaum
- Elvidge
- Eric Chuah
- Eric Minwei Liu
- Eric Thompson
- Erik Larsson
- Erik Zmuda
- Erin Curley
- Eryn M. Godwin
- Esther Drill
- Evgeny Mozgovoy
- Fanny Dao
- Faraggi
- Fawcett
- Floris P. Barthel
- Forbes
- Francisco Sanchez-Vega
- Fréderic Chibon
- Gabriel L. Sica
- Gad Getz
- Galiya Setdikova
- Gaujoux
- George D. Demetri
- Georgy Manikhas
- Gibault
- Gonzalez-Angulo
- Gordon B. Mills
- Gordon Saksena
- Guo
- Hailei Zhang
- Hanluen Kuo
- Harman Sekhon
- Heather K. Schmidt
- Heidi J. Sofia
- Hennessy
- Hongxin Zhang
- Hsiao-Wei Chen
- Hsu
- Hu
- Huang
- HĂ©lias-Rodzewicz
- Ian J. Davis
- Ilya Shmulevich
- Ina Felau
- Irene Li
- Italiano
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- Janae V. Simons
- Janet E. Novak
- Jason L. Hornick
- Jason Roszik
- Jay Bowen
- Jean C. Zenklusen
- Jeff Boyd
- Jeffrey Roach
- Jennifer Eschbacher
- Jenny Lester
- Jeremy Parfitt
- Jia Liu
- Jianjiong Gao
- Jiashan (Julia) Zhang
- Jing Wang
- Joel S. Parker
- Joesph Bennett
- Johanna Gardner
- John A. Demchok
- John A. Martignetti
- John Bartlett
- John N. Weinstein
- John Wrangle
- Joseph Paulauskis
- Joshua Armenia
- Juliann Shih
- Julie M. Gastier-Foster
- Juneko E. Grilley-Olson
- Jung
- Juok Cho
- Kadoch
- Karen Mungall
- Kasar
- Katayoon Kasaian
- Katherine A. Hoadley
- Keila E. Torres
- Keith Delman
- Kelly Higgins
- Kevin B. Jones
- Kjong-Van Lehmann
- Koboldt
- Koh
- Konstantin Fedosenko
- Korn
- Kovatcheva
- Kristen M. Leraas
- Lara E. Davis
- Larson
- Lauren Byers
- Laurence Baker
- Lawrence
- Laxmi Lolla
- Lee A.D. Cooper
- Leigh B. Thorne
- Leona A. Doyle
- Leslie Cope
- Lesluyes
- Li
- Li
- Li
- Li
- Li
- Li
- Li Ding
- Liau
- Liming Yang
- Lisa Iype
- Lisa Wise
- Lisle E. Mose
- Lixia Diao
- Lori Boice
- Lucinda A. Fulton
- Ludmila Danilova
- Lynda Chin
- Madhusmita Behera
- Marc Ladanyi
- Marco A. Marra
- Mariani
- Mark Gerken
- Martin L. Ferguson
- Mary Iacocca
- Matt van de Rijn
- Matthew D. Wilkerson
- Matthew G. Cordes
- Matthew G. Soloway
- Matthew H. Bailey
- Matthew L. Anderson
- Matthew Meyerson
- Matthew Wyczalkowski
- McCarroll
- McKenna
- Mei Huang
- Mermel
- Michael Birrer
- Michael D. McLellan
- Michael Dubina
- Michael Ittmann
- Michael Mayo
- Michael Nalisnik
- Michael S. Lawrence
- Michael S. Noble
- Miruna Balasundaram
- Mo
- Moiz S. Bootwalla
- Narciso Olvera
- Nicholas Socci
- Nikolaus Schultz
- Nils Gehlenborg
- Nilsa C. Ramirez
- Nina Thiessen
- Niu
- Noreen Dhalla
- Olga Potapova
- Olga Voronina
- Olshen
- Oxana Paklina
- Pan Tong
- Patricia Castro
- Patricia Swanson
- Paul Spellman
- Pavana Anur
- Payal Sipahimalani
- Pei Lin
- Peter Dottino
- Peter W. Laird
- Phil DiSaia
- Phillip H. Lai
- Pidsley
- Piotr A. Mieczkowski
- PĂ©rot
- Qiang Sun
- Qingsong Gao
- Radenbaugh
- Rameen Beroukhim
- Ramos
- Raphael E. Pollock
- Rashi Naresh
- Rashna Madan
- Reanne Bowlby
- Rebecca Carlsen
- Rehan Akbani
- Reinius
- Richard A. Moore
- Richard F. Riedel
- Richard K. Wilson
- Ritika Kundra
- Robert A. Holt
- Robert G. Maki
- Robert Penny
- Robert S. Fulton
- Roel Verhaak
- Ronglai Shen
- Roy Tarnuzzer
- Saianand Balu
- Sally N. Adebamowo
- Sam Meier
- Samuel Singer
- Sanghoon Lee
- Sara Sadeghi
- Saunders
- Schwartz
- Scott Frazer
- Scott Morris
- Sedgewick
- Seo
- Shabalin
- Shaowu Meng
- Sheila M. Reynolds
- Shen
- Shital Hobensack
- Sioletic
- Smigielski
- Stacey B. Gabriel
- Stephen B. Baylin
- Steven E. Schumacher
- Steven J.M. Jones
- Stuart R. Jefferys
- Sudha Chudamani
- Suresh S. Ramalingam
- Tamara Kalir
- Taofeek K. Owonikoko
- Tara M. Lichtenberg
- Tara Skelly
- Taylor
- Taylor
- Teniola Akeredolu
- Thèrése Bocklage
- Tibes
- Timothy Defreitas
- Tina Wong
- Todd Pihl
- Tom Bodenheimer
- Troy Shelton
- Tusher
- Umadevi Veluvolu
- Venkata Yellapantula
- Victoria Fulidou
- W. Kimryn Rathmell
- Wang
- Wang
- Wenbin Liu
- Wilkerson
- Wilks
- Winghing Wong
- Xin Hu
- Yan Shi
- Yasin Senbabaoglu
- Ye
- Ye Wu
- Yeung
- Yiling Lu
- Yulia Newton
- Yunhu Wan
- Yussanne Ma
- Zachary Heins
- Zack
- Zhining Wang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study